Bioinformatics Seminar Series, Spring 2020

February 14, 2020 - 2:30 PM to 3:30 PM
Bioinformatics 105

Dr. Jean-Francois Gout

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Title: Molecular mechanisms of transcriptional fidelity.
 
Abstract: Accurate replication and transcription are two of the most fundamental processes needed by all forms of cellular life. While mutation rates studies have allowed many discoveries regarding molecular mechanisms governing the fidelity of DNA replication, similar studies on the fidelity of transcription suffer from the unique technical challenges in identifying transcription errors (base-substitutions, insertions, deletions). Here, I will present the latest developments in the elaboration of techniques dedicated to quantify transcription error rates and the associated computational challenges. Using these new methods, we investigate the molecular mechanisms responsible for accurate transcription and their evolution across the tree of life.
Organizer: Trish Artis
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